Pickens Homes with Mixed Use Style

Welcome to Pickens, South Carolina, a charming city nestled in the heart of the Blue Ridge Mountains. Known for its rich history and warm community spirit, Pickens offers a unique blend of small-town charm and modern convenience. With a population of just over 3,000 residents, this picturesque town features beautiful landscapes, friendly neighbors, and a vibrant local culture that makes it a perfect place to call home.

Pickens is not only famous for its stunning natural beauty but also for its diverse real estate options, including homes with a mixed-use style. These innovative properties beautifully combine residential and commercial spaces, allowing homeowners to live, work, and play all in one location. Imagine waking up in your cozy abode and stepping right into your own boutique, café, or office space—all just a few steps away! This unique approach to living is perfect for entrepreneurs and those who appreciate the convenience of having everything at their fingertips.

The city is also home to several parks, recreational facilities, and community events, fostering a sense of belonging and connection among residents. With a thriving downtown area featuring local shops, restaurants, and art galleries, Pickens is a vibrant hub for creativity and commerce.

Whether you’re looking to start a new business, enjoy the tranquility of nature, or immerse yourself in a close-knit community, Pickens, SC, with its mixed-use homes, offers the perfect blend of lifestyle and opportunity. Discover the charm of Pickens and find your dream home today!

Newest Pickens Homes with Mixed Use Style

$995,000

3 Beds ⋅ 2.5 Baths

I am pleased to present a unique real estate opportunity in the heart of Upstate South Carolina: a beautiful traditional home accompanied by the turnkey Laurel Mountain Inn. The custom-built primary residence features over 2,300 square feet of craftsmanship with an open floor plan, a main-level primary bedroom, three bedrooms, 2.5 bathrooms, and an attached office. The property also includes a full walkout basement ready to be finished as additional living space or a rental unit. The adjacent Laurel Mountain Inn sits on nearly seven acres next to Table Rock State Park. This fully operational, five-room income-producing property comes with a complete vendor list and an excellent reputation. Situated off Scenic Highway 11 near Caesars Head and Lake Keowee, it is a premier destination for nature enthusiasts and an ideal investment for hospitality entrepreneurs or event venue developers. While offering a private mountain lifestyle, the property remains conveniently located 30 minutes from Travelers Rest and 45 minutes from downtown Greenville. Showings are limited to qualified buyers and require a minimum 3-hour notice.

133 Hiawatha Trail, Pickens

$680,000

2 Beds ⋅ 1 Baths

Tons of options with this new property featuring 23+ acres of mature forests with a new garage/ cabin combo. You can live in it as-is, or live in it while you built your main home, then use the current home as a guest house. The home is built with heavy duty all wood construction, but the walls are not load bearing, so you could take all of them out and convert the entire building into a workshop/ garage, or eliminate the garage and turn it all into living space. It would be great as a garage as the floors are 6" thick concrete, with 12' ceilings, plus its wired for heavy duty 220 garage appliances. The property offers 3 creeks, hardwood forests, multiple gardens with a solar powered creek watering system, ATV/ bike trails, walking paths along the creek. This property would serve as a great multifamily compound or as a ranch. Its unrestricted, so use your imagination. The property goes up the hill and has a great homesite with panoramic views .

3306 Moorefield Memorial Highway, Pickens

$275,000

3 Beds ⋅ 2 Baths

MIXED-USE INVESTMENT OPPORTUNITY — 4612 Moorefield Memorial Highway, Pickens, SC Positioned along Moorefield Memorial Highway with approximately 7,000 vehicles passing daily, this versatile mixed-use property offers a unique combination of commercial space, residential income, visibility, and room to grow. Located just blocks from the Pickens County offices, the property is well suited for an investor seeking multiple income opportunities or an owner-operator looking to combine business operations with an income-producing residential component. The main level is configured for business use and features two private office spaces, a large reception or waiting area, a galley kitchen, full bathroom, and utility room with laundry hookups. The flexible layout can accommodate a variety of professional, service, or retail-oriented uses, including contractors, insurance or professional offices, medical or dental practices, automotive-related businesses, and more. Upstairs, a separate one-bedroom apartment includes its own kitchen, full bathroom, and living area. A long-term tenant is currently in place, providing an existing source of rental income while the commercial portion is occupied or leased. Outside, the property offers ample off-street parking for employees and customers, along with a large fenced area at the rear of the property. The additional space provides flexibility for equipment, vehicles, storage, or potential future improvements, subject to applicable zoning and approvals. For an investor, the property presents multiple potential income streams within a single asset. For an owner-operator, it offers the opportunity to establish a business in a visible highway location while generating supplemental rental income upstairs. Commercial flexibility. Residential income. Highway visibility. Room for future growth. 4612 Moorefield Memorial Highway brings several valuable components together in one property. All information is deemed accurate but not guaranteed. Buyers should independently verify property details, permitted uses, traffic counts, zoning, and development potential. Contact the listing agent for additional information and access instructions.

4612 Moorefield Memorial Highway, Pickens

$270,000

1 Baths

Storybook property with right on the Oolenoy River. There are numerous options with this property, it features an office/ efficiency apartment with a single car garage that could be finished into a bedroom. You could build onto this or keep it as-is while you built your new home. It could also be a guest quarters or maybe a weekend rental. The land is mostly pasture, so it would be great as a farm, campground, maybe a music venue, or even a combination of all of these. This property features 3.2 acres, but the best feature of this property is the beautiful and relaxing sound of the rushing waters of the river. It also has a very nice creek running along the full length of the property that joins the river. All of this is right in the heart of one of the most beautiful parts of the Upstate and nestled at the foot of the mountains.

716 Sliding Rock Road, Pickens

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The Listings data contained on this website comes from various participants of The Multiple Listing Service of Greenville, SC, Inc. Internet Data Exchange. IDX information is provided exclusively for consumers' personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing. The properties displayed may not be all the properties available. All information provided is deemed reliable but is not guaranteed. © 2026 Greater Greenville Association of REALTORS®. All Rights Reserved. Last Updated